Rashtriya Ayurveda Vidyapeeth

• Brilatvasavalcha-1, Brihatvasavaleha-2, Briharvasavaleha-3 should be taken standard.

• There is no significant difference in manufacturing process of Brihatvesvaleha-1,
Brihatvasavalcha-2 & Brihatavasavalcha-3.

• All the formulations showed highly significant results in cardinal symptoms (P-0.001)
But the percentage of relief was seen more (58.53%) in Brihatavasavaleha-2 (Group B)
followed by (51.98%) in Brihatavasavaleha-3 (Group-C) and Brikarvasavaleha-1 (Group
(47,61%) in comparison to each other.

• Overall effect of treatment: In Group-A Brihatavasavaleha-1, 45% patient's attained
moderate improvement while 55% patients attained mild improvement. In Group-B
Brihatavasavaleha-2, 100% patients attain moderate improvement. And in Group-C
Brihasavasavaleha-3, 75% patients attained moderate improvement while 20% patients
attained mild improvement and 5% patients attained markedly improvement.

• No remarkable side effects of all three formulations observed during the study.

All the three samples of Brihatavasavaleha are potent drug for disease Shwasa roga,

 The following points can be derived as conclusion at the end of this study -
• Formulation as Pashanbhinna Rasa has not been found described by name in Bruhattrayi.
• In both pharmaceuticals process, weight loss of Pashanbhinna Rasa- B was more than Pashanbhinna Rasa - A
• It found that the chakrikas were melt and converted in to a bolus wet condition in Dola yantra processes but in Valuka yantra processes all the chakrikas adhere each other and found in dry condition.
• Analytical data of Pashanbhinna Rasa - A & B was the ash value, acid insoluble ash, total mercury & LOD were higher in Pashanbhinna Rasa- B compared to Pashanbhinna Rasa- A. The Ph value, total sulphur, water soluble ash, water soluble extractive & alcohol soluble extractive were found higher in Pashanbhinna Rasa- A compared to Pashanbhinna Rasa- B.
• Ovarall effect of treatment:
Group- A (Pashanbhinna Rasa-A): Out of 20 patients 45% cured, 30% markedly improved, 25% moderately improved.
Group -B (Pashanabinna Rasa-B): Out of 20 patients 40% cured, 30% markedly improved, 30% moderately improved.
So, on this basis, it can be concluded that swedana in water imparts more therapeutic effect rather than valuka puta means during preparation heat given required is very less. Therefore the Group- A (Pashanbhinna Rasa-A) is found to be significantly effective as compared to Group -B (Pashanabinna Rasa-B).

 
Kaarshya is mentioned elaborately in a chapter devoted to Baalaroga in Yogaratnaakar and Bhavprakash has also discussed the disease in detail.
v It can be co related to malnutrition, though the etiology according to modern concept and ayurvedic concept vary grossly.
v Kaarshya, with Vaata as primary dosha has Rasa as its primary dushya, secondarily affecting Mamsa and Meda, too. Yashada bhasma is a proven immunomodulator, and a lesser incidence of infections is a pre requisite for normal growth speed of individuals in the growing years.
v Yashada bhasma ,a chief ingredient of the formulation has pivotal role in curing Rasapradoshaja vikaara. Laghumaalini vasanta rasa with synergistic effect of all the ingredients works on bringing samaavastha of Jatharaagni, deranged by Vaataprakopa; relieves amadosha; removes srotavarodha and restores nourishment of Rasadhaatu and thereon mamsa dhaatu and medadhaatu.
v According to modern concept, LMV replenishes Zinc deficiency, which in turn repairs the immune system and also corrects malfunction in enzymatic complexes-of which Zinc is an integral part, so it works on digestive system as well; effectualising anabolic changes.
v In Pharmaceutical study, we concluded that temperature had to be sustained at 7000 C for 45-50 minutes for proper bhasma formation in each of the seven putas.
v Better palatability was conferred by using kshaudra as sahapaan.
v The pH of Sample LMV 1 is 6.5% and the pH of Sample LMV 2 is 6.2% which showed that both samples were acidic in nature but the Sample LMV 2 was slightly more acidic than Sample LMV 1. The ash value indicates the inorganic load of a drug. There was variation in the ash value of both the samples. Ash value of Sample LMV 1 was 18.9% w/w while Ash value of Sample LMV 2 was 17.56% w/w which indicates inorganic load was higher in Sample LMV 1 than in Sample LMV 2. There was not much variation in the loss of drying of samples as it were 4.28% w/w  and 3.97% w/w in Sample LMV 1 and Sample LMV 2 respectively.
v Though both modules of the drug- LMV 1 and LMV 2 gave beneficial results, but the results were statistically more significant in Group B than in Group –A. so, it could be concluded that LMV 2, with an added ingredient-Hingula which is sarvadoshanaashak and jatharaagni pradeepaka is more effective than LMV 1 in treating Kaarshya.
 

v No study has been conducted on Kanakarishtain vicharchika.

v Mostly Ashawa andArishta are made from sugar and jaggery.But Kanakarishta is the exception of them, becausein the referanceof kanakarishta honeyis used for sweetning.
v In this present study total 5 patient (16.66%) have got marked improvement while 12 patients (40%) were Moderately improved and 13patient (43.33%) had got mild improvement.
v At the end of prepration, Alcohol content of the kankarishta was 5.04.